Detailed view for LOAG_00665

Basic information

TDR Targets ID: 946148
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.0958 | Length (AA): 3727 | MW (Da): 422298 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00622   SPRY domain
PF01365   RIH domain
PF02026   RyR domain
PF02815   MIR domain
PF08709   Inositol 1,4,5-trisphosphate/ryanodine receptor

Gene Ontology

Mouse over links to read term descriptions.
GO:0070588   GO:calcium ion transmembrane transport  

GO:0016020   membrane  
GO:0005515   protein binding  
GO:0005262   calcium channel activity  
GO:0005219   ryanodine-sensitive calcium-release channel activity  
GO:0006816   calcium ion transport  

Metabolic Pathways

Calcium signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 209 5y9v (A) 14 201 65.00 0 1 0.715321 -0.52
16 663 5x9z (A) 7 694 20.00 0 1 0.0926664 1.63
16 208 3ila (I) 12 204 66.00 0.021 1 -0.0312157 0.54
227 530 4i96 (A) 219 532 42.00 0 1 0.412667 -0.13
844 1046 4erv (A) 2598 2798 31.00 0 1 0.402267 -0.33
854 1047 5c30 (A) 861 1054 42.00 0 1 0.605153 -0.85
1069 1233 4p9i (A) 1086 1250 54.00 0 1 0.707372 -0.65
1069 1242 4p9j (C) 1073 1246 48.00 0 1 0.681786 -0.67
2886 3086 4esu (A) 2734 2939 38.00 0 1 0.433931 -0.19
2886 3086 4etv (B) 2699 2904 47.00 0.000000000014 1 0.0769308 0.48
2887 3086 4etv (A) 2700 2904 42.00 0 1 0.517662 -0.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129275)

Species Accession Gene Product
Brugia malayi Bm1_45145   Ryanodine Receptor TM 4-6 family protein
Caenorhabditis elegans CELE_K11C4.5   Protein UNC-68, isoform A
Drosophila melanogaster Dmel_CG10844   Ryanodine receptor
Echinococcus granulosus EgrG_000544500   ryanodine receptor 44f
Echinococcus granulosus EgrG_000544400   ryanodine receptor 44f
Echinococcus multilocularis EmuJ_000544500   ryanodine receptor 44f
Echinococcus multilocularis EmuJ_000544400   ryanodine receptor 44f
Homo sapiens ENSG00000196218   ryanodine receptor 1 (skeletal)
Homo sapiens ENSG00000198626   ryanodine receptor 2 (cardiac)
Homo sapiens ENSG00000198838   ryanodine receptor 3
Loa Loa (eye worm) LOAG_00667   ryanodine receptor
Loa Loa (eye worm) LOAG_00666   ryanodine receptor
Loa Loa (eye worm) LOAG_00665   hypothetical protein
Mus musculus ENSMUSG00000021313   ryanodine receptor 2, cardiac
Mus musculus ENSMUSG00000030592   ryanodine receptor 1, skeletal muscle
Mus musculus ENSMUSG00000057378   ryanodine receptor 3
Schistosoma japonicum Sjp_0030030   ko:K05327 ryanodine receptor, invertebrate, putative
Schistosoma japonicum Sjp_0001530   Ryanodine receptor 3, putative
Schistosoma japonicum Sjp_0020010   ko:K04963 ryanodine receptor 3 (brain), putative
Schistosoma mansoni Smp_163570   ryanodine receptor related
Schmidtea mediterranea mk4.006247.02  
Schmidtea mediterranea mk4.005685.00   Ryanodine receptor 44F
Schmidtea mediterranea mk4.021380.01  
Schmidtea mediterranea mk4.005685.02   Ryanodine receptor 44F
Schmidtea mediterranea mk4.021380.00  
Schmidtea mediterranea mk4.006247.04  
Schmidtea mediterranea mk4.006247.00  
Schmidtea mediterranea mk4.035168.00  
Schmidtea mediterranea mk4.010081.01  
Schmidtea mediterranea mk4.021380.02  
Schmidtea mediterranea mk4.005685.03   Ryanodine receptor 44F
Schmidtea mediterranea mk4.034748.00  
Schmidtea mediterranea mk4.010081.00  
Schmidtea mediterranea mk4.029716.00   Ryanodine receptor 44F
Schmidtea mediterranea mk4.005685.04  
Schmidtea mediterranea mk4.010081.02  
Schmidtea mediterranea mk4.005685.05  
Schmidtea mediterranea mk4.010081.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Drosophila melanogaster Ryanodine receptor Compounds References
Bemisia tabaci Ryanodine receptor Compounds References
Mus musculus Ryanodine receptor 3 Compounds References
Spodoptera exigua Ryanodien receptor Compounds References
Oryctolagus cuniculus Ryanodine receptor 1 Compounds References
Canis lupus familiaris Ryanodine receptor 2 Compounds References
Homo sapiens ryanodine receptor 1 (skeletal) Compounds References
Mus musculus ryanodine receptor 1, skeletal muscle Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0041 0.4486 0.7095
0.0347 0.6049 1
0.0125 0.2722 0.5864
0.1777 0.4281 0.6428
0.0878 0.5962 1
0.0042 0.4069 0.705
0.0105 0.3638 0.3827
0.0348 0.5805 1
0.0116 0.2678 0.4099
0.0204 0.3151 0.3211
0.0235 0.5115 1
0.1562 0.6237 1
0.0409 0.6201 1
0.0304 0.5494 1
0.0349 0.5835 1
0.0491 0.4626 0.7302
0.0639 0.3581 0.4977
0.0666 0.3611 0.5042
0.0349 0.5835 1
0.0306 0.4062 1
0.1646 0.3367 0.5829
0.0116 0.3331 0.3724
0.0332 0.3128 0.9736
0.0195 0.3685 0.3657
0.0132 0.4152 0.6907
0.0209 0.315 0.3453
0.0897 0.3958 0.5728
0.0161 0.378 0.6324
0.1101 0.3991 0.3991
0.0285 0.3844 1
0.0283 0.337 1
0.0946 0.6356 1
0.0633 0.3621 0.5116
0.0204 0.3151 0.3211
0.0514 0.6203 0.6339
0.1562 0.5666 0.5665
0.0481 0.2908 0.7311
0.1963 0.65 1
0.0443 0.3388 0.8264
0.061 0.3626 1
0.1248 0.4019 0.5865
0.1786 0.6469 0.6531
0.0971 0.6114 1
0.1759 0.6285 0.7846
0.017 0.4286 0.7281
0.0203 0.5185 0.6132
0.0401 0.4825 0.4823
0.1641 0.6216 1
0.1646 0.3367 0.5829
0.0132 0.4152 0.6907
0.0283 0.337 1
0.1239 0.5805 1
0.0427 0.4492 0.7194
0.1562 0.5666 0.5665
0.0312 0.6092 0.6075
0.2044 0.6516 1
0.0311 0.5494 1
0.0443 0.3388 0.8264
0.0116 0.545 1
0.0337 0.5949 1
0.0214 0.3255 0.3315
0.0071 0.303 0.3014
0.0332 0.5494 1
0.0208 0.6077 0.6197
0.0315 0.6154 0.9267
0.11 0.6262 1
0.1562 0.5666 0.5665
0.0108 0.28 0.279
0.1656 0.5586 1
0.0216 0.2999 0.4825
0.0094 0.5472 0.769
0.0155 0.2522 0.2522
0.0241 0.4562 0.7054
0.0302 0.2643 1
0.0616 0.3592 0.5079
0.0076 0.3079 0.3404
0.0729 0.3581 0.5069
0.1646 0.3367 0.5829
0.0443 0.3388 0.8264
0.0596 0.5805 1
0.05 0.4638 0.7306
0.0491 0.4626 0.7302
0.031 0.272 1
0.1562 0.5666 0.5665
0.0319 0.5494 1
0.2001 0.6442 1
0.1589 0.6258 1
0.011 0.5928 1
0.2001 0.6442 1
0.2089 0.6439 1
0.0195 0.3685 0.3657
0.09742 0.466417 0.733237
0.0307 0.5494 1
0.0192 0.6077 0.6197
0.0043 0.4341 1
0.1332 0.5494 1
0.2001 0.6442 1
0.1646 0.3367 0.5829
0.1101 0.3991 0.3991
0.162 0.3874 0.5562
0.0084 0.2718 0.4654
0.0063 0.3763 0.3759
0.1562 0.6237 1
0.0163 0.3888 0.6324
0.09742 0.466417 0.733237
0.1697 0.4116 0.5934
0.1702 0.5805 1
0.0606 0.3634 0.5133
0.0222 0.5805 1
0.0409 0.6201 1
0.0427 0.4492 0.7194
0.0376 0.3185 0.431
0.0655 0.3614 0.5048
0.1646 0.3367 0.5829
0.0305 0.5494 1
0.199 0.4261 0.6384
0.0971 0.6114 1
0.0425 0.2753 0.7313
0.0839 0.3786 0.5392
0.0707 0.5494 1
0.0617 0.4871 0.4868
0.1332 0.5805 1
0.0305 0.5835 1
0.0226 0.3536 0.6324
0.0897 0.3958 0.5728
0.0428 0.5297 0.5295
0.0306 0.4956 0.4956
0.0482 0.5847 1
0.0639 0.3581 0.4977
0.0084 0.407 0.6834
0.1525 0.5494 1
0.0427 0.4492 0.7194
0.0443 0.3388 0.8264
0.1101 0.3991 0.3991
0.0301 0.5494 1
0.0118 0.4614 0.7263
0.0332 0.3128 0.9736
0.0425 0.2753 0.7313
0.0116 0.3237 0.6327
0.1391 0.4019 0.5862
0.0653878 0.251143 1
0.0302 0.5971 1
0.0897 0.3958 0.5728
0.0387 0.623 0.904
0.1438 0.6051 1
0.0092 0.3113 0.587
0.0443 0.3388 0.8264
0.0964 0.3685 1
0.1562 0.5666 0.5665
0.0302 0.6015 1
0.0037 0.3403 0.6186
0.1979 0.4026 0.587
0.0313 0.5494 1
0.0327 0.3015 0.5652
0.0443 0.3388 0.8264
0.1777 0.4281 0.6428
0.0427 0.3994 0.7295
0.1646 0.3367 0.5829
0.0377 0.3251 0.4385
0.0301 0.5835 1
0.0451 0.6265 1
0.0509 0.316 0.7315
0.0212 0.4519 0.4952
0.0286 0.6162 0.975
0.0321 0.5805 1
0.0836 0.3784 0.5387
0.017 0.4286 0.7281
0.0342 0.6241 1
0.0695 0.3606 0.5032
0.0346 0.6232 1
0.0716 0.357 1
0.1562 0.6237 1
0.1374 0.4019 0.5865
0.1646 0.3367 0.5829
0.1562 0.5666 0.5665
0.0317 0.5494 1
0.1438 0.6051 1
0.0455 0.3376 0.4652
0.0163 0.3888 0.6324
0.1329 0.5805 1
0.0314 0.6169 1
0.1562 0.6237 1
0.0199 0.6051 0.6172
0.1646 0.3367 0.5829
0.0092 0.3113 0.587
0.1646 0.3367 0.5829
0.0841 0.2741 1
0.0936 0.3984 0.5782
0.0301 0.2815 0.7892
0.0402 0.3215 0.7283
0.0991 0.5494 1
0.0332 0.3128 0.9736
0.0376 0.3573 0.3573
0.1411 0.5494 1
0.0479 0.2848 0.7307
0.0427 0.3994 0.7295
0.0327 0.6097 1
0.0169 0.4036 0.6803
0.0639 0.3581 0.4977
0.0156 0.2924 0.2897
0.0237 0.407 0.6834
0.0127 0.3029 0.4037
0.1562 0.5666 0.5665
0.19 0.3005 0.3805
0.0427 0.3994 0.7295
0.0446 0.3501 1
0.0294 0.6117 1
0.0296 0.2821 1
0.0216 0.2999 0.4825
0.0377 0.3251 0.4385
0.0849 0.3809 0.546
0.0676 0.3614 1
0.1646 0.3367 0.5829
0.0196 0.6077 0.6197
0.0226 0.3536 0.6324
0.0377 0.3213 0.431
0.0096 0.5805 1
0.1303 0.5494 1
0.1761 0.6278 1
0.0443 0.2595 1
0.0377 0.3251 0.4385
0.0443 0.3388 0.8264
0.0964 0.3685 1
0.0823 0.3787 0.5392
0.039 0.6051 1
0.2183 0.4012 0.5836
0.0334 0.6051 1
0.0327 0.3015 0.5652
0.0341 0.5494 1
0.0286 0.6161 0.9703
0.0042 0.4069 0.705
0.1418 0.4297 0.6461
0.1589 0.6258 1
0.1562 0.6256 1
0.1286 0.5494 1
0.0152 0.3536 0.6324
0.0616 0.3592 0.5079
0.0155 0.2522 0.2522
0.1759 0.6285 0.7846
0.0151 0.4354 0.4488
0.1646 0.3367 0.5829
0.0886 0.5494 1
0.113 0.4441 0.9608
0.0347 0.6049 1
0.11 0.6262 1
0.0769 0.3788 0.5394
0.0204 0.3151 0.3211
0.0307 0.5494 1
0.1562 0.5666 0.5665
0.0129 0.545 1
0.0316 0.4621 0.7298
0.0247 0.6174 1
0.0122 0.5494 1
0.0491 0.4626 0.7302
0.0151 0.4354 0.4488
0.0106 0.4314 1
0.1562 0.6237 1
0.0156 0.2924 0.2892
0.019 0.5611 0.5611
0.1827 0.5744 1
0.162 0.3874 0.5563
0.1304 0.5494 1
0.1646 0.3367 0.5829
0.1646 0.3367 0.5829
0.0116 0.2678 0.4099
0.0903 0.5494 1
0.0317 0.5835 1
0.1589 0.5792 1
0.017 0.4286 0.7281
0.0633 0.3621 0.5116
0.0037 0.3403 0.6186
0.0815 0.2914 0.4582
0.0116 0.5494 1
0.1646 0.3367 0.5829
0.0305 0.5494 1
0.1418 0.4297 0.6461
0.0491 0.4626 0.7302
0.0378 0.7551 1
0.0307 0.5494 1
0.1786 0.6469 0.6531
0.0057 0.3729 0.3729
0.0409 0.6201 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_00665 (Loa Loa (eye worm)), hypothetical protein
Title for this comment
Comment